Sunday, 13 April 2014

Green tomatoes help develop bigger, stronger muscles

A new study suggests that green tomatoes might hold the solution to bigger, stronger muscles.

Using a screening methodology that previously known a compound in apple peel as a muscle-boosting agent, a team of University of Iowa scientists has currently discovered that tomatidine, a compound from green tomatoes, is even stronger for building muscle and protecting against muscle atrophy.

Muscle atrophy, or wasting, is caused by aging and a variety of diseases and injuries, including cancer, heart condition, and orthopedic injuries, to call some. It makes people weak and worn-out, impairs physical activity and quality of life, and predisposes people to falls and fractures. The condition affects over fifty million Americans annually, together with thirty million people over age sixty, and sometimes forces people into nursing homes or rehabilitation facilities.

"Muscle atrophy causes several issues for people, their families, and also the health care system generally," Christopher Adams, M.D., Ph.D., UI professor of medicine and molecular physiology and biophysics, said.

"However, we lack a good thanks to prevent or treat it. Exercise actually helps, however it isn't enough and not very possible for several those that are unwell or injured," he said.

In a new study, Adams searched for atiny low molecule compound that may be used to treat muscle atrophy.

He zeroed in on tomatidine using a systems biology tool known as the connectivity Map, which was developed at the Broad Institute of mit and harvard university.

Adams discovered that tomatidine generates changes in gene expression that are primarily opposite to the changes that occur in muscle cells once folks are affected by muscle atrophy.

After distinctive tomatidine, Adams and his team tested its effects on striated muscle. They initial discovered that tomatidine stimulates growth of cultured muscle cells from humans.

Their next step was to feature tomatidine to the diet of mice. They found that healthy mice supplemented with tomatidine grew larger muscles, became stronger and could exercise longer. And, most significantly, they found that tomatidine prevented and treated muscle atrophy.

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